Assessment of HLADP gene rs3128917 and rs9380343 polymorphisms in chronic HBV infection


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Akgollu E.

TURKISH JOURNAL OF GASTROENTEROLOGY, cilt.30, ss.616-623, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 30 Konu: 7
  • Basım Tarihi: 2019
  • Doi Numarası: 10.5152/tjg.2019.18480
  • Dergi Adı: TURKISH JOURNAL OF GASTROENTEROLOGY
  • Sayfa Sayıları: ss.616-623

Özet

Background/Aims: About 400 million people worldwide have been exposed to Hepatitis B (HBV) infection. A range of 10%-15% of chronic HBV carriers may present with various liver diseases including cirrhosis and hepatic cancer. The chronicity or clearance of HBV infection is dependent on viral and genetic variables. Genome-wide association studies (GWAS) have reported that the variants of human leukocyte antigen (HLA), rs3128917 and rs9380343, are significantly related to persistent HBV infection. HLA molecules are responsible for introducing various antigens into the immune system. These variants might affect antigen presentation by influencing HLA mRNA expression, therefore, antigen presentation may not be performed properly.