Impact of intranasal application of nerve growth factor on the olfactory epithelium in rats with chemically induced diabetes
ULTRASTRUCTURAL PATHOLOGY, cilt.42, sa.3, ss.246-254, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 42 Sayı: 3
- Basım Tarihi: 2018
- Doi Numarası: 10.1080/01913123.2018.1463337
- Dergi Adı: ULTRASTRUCTURAL PATHOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.246-254
- Çukurova Üniversitesi Adresli: Evet
Özet
Recent studies suggest that nerve growth factor (NGF) protects olfactory cells and axons from injury in vitro. Eighteen Wistar-Albino rats randomly divided into three groups: control group, diabetic group without NGF, and diabetic with NGF. Intranasal NGF (6 mu g/day) was administered over a 5-day period. At the end of 30days, the olfactory epithelium (OE) of NGF-applied diabetic rats regenerated, the epithelium thickness was significantly higher, and caspase-3 expression was not significantly different from the control. The current results demonstrate that intranasally administered NGF significantly reversed OE morphological changes in diabetes by decreasing diabetes-related cell death and inflammation.