Impact of intranasal application of nerve growth factor on the olfactory epithelium in rats with chemically induced diabetes

YALIM S., DAGLIOGLU K., COŞKUN G., POLAT S.

ULTRASTRUCTURAL PATHOLOGY, cilt.42, sa.3, ss.246-254, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1080/01913123.2018.1463337
  • Dergi Adı: ULTRASTRUCTURAL PATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.246-254
  • Çukurova Üniversitesi Adresli: Evet

Özet

Recent studies suggest that nerve growth factor (NGF) protects olfactory cells and axons from injury in vitro. Eighteen Wistar-Albino rats randomly divided into three groups: control group, diabetic group without NGF, and diabetic with NGF. Intranasal NGF (6 mu g/day) was administered over a 5-day period. At the end of 30days, the olfactory epithelium (OE) of NGF-applied diabetic rats regenerated, the epithelium thickness was significantly higher, and caspase-3 expression was not significantly different from the control. The current results demonstrate that intranasally administered NGF significantly reversed OE morphological changes in diabetes by decreasing diabetes-related cell death and inflammation.