Impact of intranasal application of nerve growth factor on the olfactory epithelium in rats with chemically induced diabetes


YALIM S., DAGLIOGLU K., COŞKUN G. , POLAT S.

ULTRASTRUCTURAL PATHOLOGY, cilt.42, ss.246-254, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 42 Konu: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1080/01913123.2018.1463337
  • Dergi Adı: ULTRASTRUCTURAL PATHOLOGY
  • Sayfa Sayıları: ss.246-254

Özet

Recent studies suggest that nerve growth factor (NGF) protects olfactory cells and axons from injury in vitro. Eighteen Wistar-Albino rats randomly divided into three groups: control group, diabetic group without NGF, and diabetic with NGF. Intranasal NGF (6 mu g/day) was administered over a 5-day period. At the end of 30days, the olfactory epithelium (OE) of NGF-applied diabetic rats regenerated, the epithelium thickness was significantly higher, and caspase-3 expression was not significantly different from the control. The current results demonstrate that intranasally administered NGF significantly reversed OE morphological changes in diabetes by decreasing diabetes-related cell death and inflammation.