gamma-Carboline AC190 analogues via palladium catalysed allene insertion stereo and regioselective 3-and 5-component cascades

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DÖNDAŞ H. A., Hempshall A., Narramore S., Kilner C., Fishwick C. W. G., Grigg R.

TETRAHEDRON, vol.72, no.10, pp.1316-1329, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 72 Issue: 10
  • Publication Date: 2016
  • Doi Number: 10.1016/j.tet.2016.01.025
  • Journal Name: TETRAHEDRON
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1316-1329
  • Çukurova University Affiliated: No


gamma-Carbolines were prepared from pyrido[4,3-b]-5H-indoles via Pd(0)-catalysed, stereo and regioselective allene/uridine allene insertion 3- and 5-component cascades. This versatile reaction sequence gives a range of structurally diverse carboline derivatives and tolerates a broad range of substrates. The power of this approach has been harnessed to produce gamma-carboline based HDAC inhibitors. (C) 2016 Elsevier Ltd. All rights reserved.