gamma-Carboline AC190 analogues via palladium catalysed allene insertion stereo and regioselective 3-and 5-component cascades

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DÖNDAŞ H. A., Hempshall A., Narramore S., Kilner C., Fishwick C. W. G., Grigg R.

TETRAHEDRON, cilt.72, sa.10, ss.1316-1329, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 72 Sayı: 10
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.tet.2016.01.025
  • Dergi Adı: TETRAHEDRON
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1316-1329
  • Çukurova Üniversitesi Adresli: Hayır

Özet

gamma-Carbolines were prepared from pyrido[4,3-b]-5H-indoles via Pd(0)-catalysed, stereo and regioselective allene/uridine allene insertion 3- and 5-component cascades. This versatile reaction sequence gives a range of structurally diverse carboline derivatives and tolerates a broad range of substrates. The power of this approach has been harnessed to produce gamma-carboline based HDAC inhibitors. (C) 2016 Elsevier Ltd. All rights reserved.