Synthesis and biological evaluation of platinum complexes of highly functionalized aroylaminocarbo-N-thioyl prolinate containing tetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione moieties
INORGANICA CHIMICA ACTA, cilt.498, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 498
- Basım Tarihi: 2019
- Doi Numarası: 10.1016/j.ica.2019.119154
- Dergi Adı: INORGANICA CHIMICA ACTA
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Anahtar Kelimeler: Platinum complexes, Aminocarbothiol, Antibacterial, Antifungal, CRYSTAL-STRUCTURE, PYRROLIDINE, ANTITUMOR, ANTIBACTERIAL, DERIVATIVES, BEARING, SERIES, PT(II)
- Çukurova Üniversitesi Adresli: Hayır
Özet
Platinum complexes, derived from two families of bidentate funcionalized aroylaminocarbo-N-thyoyl prolinates, are prepared using mild conditions from prolinates, which are available via 1,3-dipolar cycloadditions. The resulting four coordinated neutral square-planar platinum(II) complexes are very stable and are fully characterized. Their structures are determined by spectroscopic and analytical methods and one of them by single crystal X-ray diffraction analysis. In this pattern, the platinum exhibits distorted square planar geometry, with cis-bond angles ranging from 89.42(2) and 94.37(6)degrees and trans-bond angles of 176.19(6) and 177.08(6)degrees, respectively. Anti(myco)bacterial and antifungal studies of all these new compounds are carried out under standardized protocols.