Incidence and Prognostic Importance of Molecular Genetic Defects in Children with Acute Myeloblastic Leukemia

Komur M., Erbey F., Bayram I. , Tanyeli A.

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, cilt.11, ss.1393-1395, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 11 Konu: 5
  • Basım Tarihi: 2010
  • Sayfa Sayıları: ss.1393-1395


Introduction: Acute myeloblastic leukemia (AML) accounts for 15 to 25 percent of childhood acute leukemias. The most common genetic abnormalities seen in pediatric AML patients are AML1-ETO, PML-RAR alpha and CBFB-MYH11 genes resulting in t(8;21), t(15;17) and inv(16). These genetic defects are seen in approximately 20-25% of AML patients. Objective: We investigated in this study, incidence and prognostic significance of the AML1-ETO, PML-RAR alpha and CBFB-MYH11 genes in children with AML. Materials and Methods: The authors analyzed 34 children with AML using the real time-polymerase chain reaction for AML1-ETO, PML-RAR alpha and CBFB-MYH11 genes. Results: Of the patients, 8.8% were positive for t(8;21), 8.8% for t(15;17) and 3% for inv(16). There were a statistically significant differences between 48 month overall survival rates of the patients positive and negative for t(8;21), t(15;17) and inv(16). Conclusion: It was concluded that t(15;17), t(8;21) and inv(16) impact on disease prognosis positively, but comprehensive studies with larger patient series are now needed for confirmation.