Incidence and Prognostic Importance of Molecular Genetic Defects in Children with Acute Myeloblastic Leukemia

Komur M., Erbey F., Bayram I., Tanyeli A.

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, cilt.11, sa.5, ss.1393-1395, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 5
  • Basım Tarihi: 2010
  • Dergi Adı: ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1393-1395
  • Çukurova Üniversitesi Adresli: Evet

Özet

Introduction: Acute myeloblastic leukemia (AML) accounts for 15 to 25 percent of childhood acute leukemias. The most common genetic abnormalities seen in pediatric AML patients are AML1-ETO, PML-RAR alpha and CBFB-MYH11 genes resulting in t(8;21), t(15;17) and inv(16). These genetic defects are seen in approximately 20-25% of AML patients. Objective: We investigated in this study, incidence and prognostic significance of the AML1-ETO, PML-RAR alpha and CBFB-MYH11 genes in children with AML. Materials and Methods: The authors analyzed 34 children with AML using the real time-polymerase chain reaction for AML1-ETO, PML-RAR alpha and CBFB-MYH11 genes. Results: Of the patients, 8.8% were positive for t(8;21), 8.8% for t(15;17) and 3% for inv(16). There were a statistically significant differences between 48 month overall survival rates of the patients positive and negative for t(8;21), t(15;17) and inv(16). Conclusion: It was concluded that t(15;17), t(8;21) and inv(16) impact on disease prognosis positively, but comprehensive studies with larger patient series are now needed for confirmation.