Current Trends towards the Synthesis of Bioactive Heterocycles and Natural Products Using 1,3-Dipolar Cycloadditions (1,3-DC) with Azomethine Ylides

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DÖNDAŞ H. A., de Gracia Retamosa M., Sansano J. M.

SYNTHESIS-STUTTGART, vol.49, no.13, pp.2819-2851, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 49 Issue: 13
  • Publication Date: 2017
  • Doi Number: 10.1055/s-0036-1588423
  • Journal Name: SYNTHESIS-STUTTGART
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2819-2851
  • Keywords: azomethine ylide, dipolar cycloaddition, natural products, bioactivity, heterocycles, ASYMMETRIC 3+2 CYCLOADDITION, BIOLOGY-ORIENTED SYNTHESIS, ONE-POT SYNTHESIS, DIASTEREOSELECTIVE SYNTHESIS, REGIOSELECTIVE SYNTHESIS, RING-SYSTEM, ENANTIOSELECTIVE CONSTRUCTION, STEREOSELECTIVE-SYNTHESIS, PYRROLIDINE DERIVATIVES, MULTICOMPONENT REACTION
  • Çukurova University Affiliated: No

Abstract

This review summarizes the trends in the formation of complex or not so complex heterocyclic structures through 1,3-dipolar cycloadditions of azomethine ylides. Diastereo- and enantioselective processes as well as non-asymmetric cycloadditions constitute very important synthetic tools for achieving these compounds. This review covers the literature from 2015 through 2016 and organizes the research in terms of biologically important heterocycles and natural products from cascade 1,3-dipolar cycloadditions of azomethine ylides to the simpler forms of 1,3-dipolar cycloaddition.