Current Trends towards the Synthesis of Bioactive Heterocycles and Natural Products Using 1,3-Dipolar Cycloadditions (1,3-DC) with Azomethine Ylides

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DÖNDAŞ H. A., de Gracia Retamosa M., Sansano J. M.

SYNTHESIS-STUTTGART, cilt.49, sa.13, ss.2819-2851, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 49 Sayı: 13
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1055/s-0036-1588423
  • Dergi Adı: SYNTHESIS-STUTTGART
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2819-2851
  • Anahtar Kelimeler: azomethine ylide, dipolar cycloaddition, natural products, bioactivity, heterocycles, ASYMMETRIC 3+2 CYCLOADDITION, BIOLOGY-ORIENTED SYNTHESIS, ONE-POT SYNTHESIS, DIASTEREOSELECTIVE SYNTHESIS, REGIOSELECTIVE SYNTHESIS, RING-SYSTEM, ENANTIOSELECTIVE CONSTRUCTION, STEREOSELECTIVE-SYNTHESIS, PYRROLIDINE DERIVATIVES, MULTICOMPONENT REACTION
  • Çukurova Üniversitesi Adresli: Hayır

Özet

This review summarizes the trends in the formation of complex or not so complex heterocyclic structures through 1,3-dipolar cycloadditions of azomethine ylides. Diastereo- and enantioselective processes as well as non-asymmetric cycloadditions constitute very important synthetic tools for achieving these compounds. This review covers the literature from 2015 through 2016 and organizes the research in terms of biologically important heterocycles and natural products from cascade 1,3-dipolar cycloadditions of azomethine ylides to the simpler forms of 1,3-dipolar cycloaddition.