The effect of mexiletine on the level of lipid peroxidation and apoptosis of endothelium following experimental subarachnoid hemorrhage


Sen O., Caner H., Aydin M. V. , Ozen O., Atalay B., Altinors N., ...Daha Fazla

NEUROLOGICAL RESEARCH, cilt.28, ss.859-863, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 28 Konu: 8
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1179/016164106x115099
  • Dergi Adı: NEUROLOGICAL RESEARCH
  • Sayfa Sayıları: ss.859-863

Özet

Objective: The role of apoptosis in etiopathogenesis of vasospasm is not clearly understood yet. It is widely accepted that protection of the endothelial cells from the process of apoptosis could have beneficial effects on cerebral vasospasm after subarachnoid hemorrhage (SAH). Mexiletine blocks sodium and calcium channels and activates ATP-sensitive K+ channels. Moreover, mexiletine is known to have potent antioxidant effects through inhibiting free-radical production.