1,3-Dipolar cycloaddition of stabilised and non-stabilised azomethine ylides derived from uracil polyoxin C (UPoC): access to nikkomycin analogues


DÖNDAŞ H. A. , Fishwick C., Grigg R., Kilner C.

TETRAHEDRON, cilt.60, sa.15, ss.3473-3485, 2004 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 60 Konu: 15
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/j.tet.2004.02.028
  • Dergi Adı: TETRAHEDRON
  • Sayfa Sayıları: ss.3473-3485

Özet

Cascade thermal and decarboxylative cycloaddition reactions of uracil polyoxin C (UPoC) with mono- and di-carbonyl compounds in the presence of a dipolarophile leads, via stabilised and non-stabilised azomethine ylides respectively, to a series of polyoxin cycloadducts related to Nikkomycin B in good to excellent yields and high diastereoselectivity. (C) 2004 Elsevier Ltd. All rights reserved.