A novel promoter controls Cyp19a1 gene expression in mouse adipose tissue


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Zhao H., Innes J., Brooks D. C. , Reierstad S., Yilmaz M. B. , Lin Z., ...Daha Fazla

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, cilt.7, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 7
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1186/1477-7827-7-37
  • Dergi Adı: REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY

Özet

Background: Aromatase, the key enzyme in estrogen biosynthesis, is encoded by the Cyp19a1 gene. Thus far, 3 unique untranslated first exons associated with distinct promoters in the mouse Cyp19a1 gene have been described (brain, ovary, and testis-specific). It remains unknown whether aromatase is expressed in other mouse tissues via novel and tissue-specific promoters.