Hepatic Malignant Melanoma in a Goat, Primary or Metastatic?

Aydogan A., Haligur M., Ozmen O.

ISRAEL JOURNAL OF VETERINARY MEDICINE, vol.68, no.2, pp.124-127, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 68 Issue: 2
  • Publication Date: 2013
  • Doi Number: 10.1111/ajco.12088
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.124-127
  • Çukurova University Affiliated: No


This report presents a case of malignant melanoma without a confirmed primary tumor in a six-year-old, female, hairy goat (Capra hircus). Macroscopically, multicentric localizations of tumor lesions were seen in liver, hepatic lymph nodes, spleen and lungs. Histopathologically, these lesions were diagnosed as malignant melanoma. Variable intracytoplasmic melanin pigments were observed in tumor cells. In addition to these findings, occasional multinucleated giant cells and common mitotic figures were detected. For immunohistochemistry, avidin-biotin-peroxidase complex (ABC) method was used with primary antibody to Melan-A and diagnosis of malignant melanoma was confirmed by immunohistochemistry. This case demonstrates the difficulties in determining a primary tumor site of a malignant melanoma in a goat.