An efficient synthetic method for the synthesis of novel chiral analogous of cilazapril and CCKA antagonists.

DÖNDAŞ H. A.

HETEROCYCLIC COMMUNICATIONS, vol.10, pp.241-247, 2004 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 10
  • Publication Date: 2004
  • Doi Number: 10.1515/hc.2004.10.2-3.241
  • Journal Name: HETEROCYCLIC COMMUNICATIONS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.241-247
  • Çukurova University Affiliated: No

Abstract

An efficient synthetic method for the synthesis of novel chiral cilazapril and analogous of CCKA-antagoriists is desciribed. The reactions proceed via acidic deprotection of tert-butyl-9 (S)-phthalimido octahydro-6, 10-dioxo- -6H-pyridazo[1,2-a] [1,2] diazepine-1(S)-carboxylate, without isolation, which then coupled with 1-methyl-3-amino-1,3-dihydro-5-phenyl-(2H)-1,4-benzodiazepine-2-one and allylamine using diethyl phosphorocyanidate as a coupling reagent afforded novel peptidomimetics in excellent yield. This sequence of reactions provided a simple four-reaction sequence and efficient synthesis of novel peptidomimetics.