HETEROCYCLIC COMMUNICATIONS, cilt.10, ss.241-247, 2004 (SCI-Expanded)
An efficient synthetic method for the synthesis of novel chiral cilazapril and analogous of CCKA-antagoriists is desciribed. The reactions proceed via acidic deprotection of tert-butyl-9 (S)-phthalimido octahydro-6, 10-dioxo- -6H-pyridazo[1,2-a] [1,2] diazepine-1(S)-carboxylate, without isolation, which then coupled with 1-methyl-3-amino-1,3-dihydro-5-phenyl-(2H)-1,4-benzodiazepine-2-one and allylamine using diethyl phosphorocyanidate as a coupling reagent afforded novel peptidomimetics in excellent yield. This sequence of reactions provided a simple four-reaction sequence and efficient synthesis of novel peptidomimetics.