Effects of specific dosages of magnesium and zinc on the teratogenicity of cadmium, nickel, and cobalt in Xenopus embryos, as assessed by the FETAX test

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Boga A., Erdogan S., Sertdemir Y.

DOSE-RESPONSE, cilt.6, sa.1, ss.16-29, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6 Sayı: 1
  • Basım Tarihi: 2008
  • Doi Numarası: 10.2203/dose-response.05-027.boga
  • Dergi Adı: DOSE-RESPONSE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.16-29
  • Çukurova Üniversitesi Adresli: Evet

Özet

The objective of this study was to determine if exposure to divalent cations, Cd2+, Ni2+, and Co2+ would lead to malformations in Xenopus laevis embryos, and whether addition of Mg2+ and Zn2+; separately and in combination, would reduce their toxicity and teratogenicity on the embryos of Xenopus laevis as assessed by 96-h FETAX tests. Results indicate that exposure to Cd2+, Ni2+ or Co2+ lead to an increase in toxicity and teratogenicity in embryos, whereas Mg2+, Zn2+, or a combination of them reduced the toxic and teratogenic effects of these divalent cations. Modulation of Cd2+, Ni2+ or Co2+ toxicity and teratogenicity by Mg2+ and Zn2+, varied with the metal. Zn2+ was observed to be a better suppressor of Co2+ toxicity and teratogenicity than Mg2+. In contrast, Ni2+, and Cd2+ teratogenicity was reduced more prominently by Mg2+. On the other hand, combination of Mg2+ and Zn2+ showed potentialization effect on all divalent cation toxicity and teratogenicity. We concluded that Mg2+ and Zn2+ reduced the toxicity and teratogenicity of Cd2+, Ni2+, Co2+.