Effects of specific dosages of magnesium and zinc on the teratogenicity of cadmium, nickel, and cobalt in Xenopus embryos, as assessed by the FETAX test


Creative Commons License

Boga A., Erdogan S., Sertdemir Y.

DOSE-RESPONSE, vol.6, no.1, pp.16-29, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 1
  • Publication Date: 2008
  • Doi Number: 10.2203/dose-response.05-027.boga
  • Journal Name: DOSE-RESPONSE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.16-29
  • Çukurova University Affiliated: Yes

Abstract

The objective of this study was to determine if exposure to divalent cations, Cd2+, Ni2+, and Co2+ would lead to malformations in Xenopus laevis embryos, and whether addition of Mg2+ and Zn2+; separately and in combination, would reduce their toxicity and teratogenicity on the embryos of Xenopus laevis as assessed by 96-h FETAX tests. Results indicate that exposure to Cd2+, Ni2+ or Co2+ lead to an increase in toxicity and teratogenicity in embryos, whereas Mg2+, Zn2+, or a combination of them reduced the toxic and teratogenic effects of these divalent cations. Modulation of Cd2+, Ni2+ or Co2+ toxicity and teratogenicity by Mg2+ and Zn2+, varied with the metal. Zn2+ was observed to be a better suppressor of Co2+ toxicity and teratogenicity than Mg2+. In contrast, Ni2+, and Cd2+ teratogenicity was reduced more prominently by Mg2+. On the other hand, combination of Mg2+ and Zn2+ showed potentialization effect on all divalent cation toxicity and teratogenicity. We concluded that Mg2+ and Zn2+ reduced the toxicity and teratogenicity of Cd2+, Ni2+, Co2+.