Synthesis of Acridine-Coumarin Hybrids

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Demirkol O., Erşatır M., Vayısoğlu Giray E. S.

Anatolian Conference 3rd on Organic Chemistry, Antalya, Türkiye, 13 - 16 Mart 2023, ss.71, (Özet Bildiri)

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Antalya
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.71
  • Çukurova Üniversitesi Adresli: Evet

Özet

Acridines (1,4-dihydropyridine derivatives) are prevalent in plant cells and possess intriguing biological features akin to those of Nicotinamide Adenine Dinucleotide (NADH), an essential coenzyme 1. Important biological features enable these compounds to be utilized as an antibacterial agent 2, in the treatment of hypertension3, as -channel openers in cardiac disorders 4, as a carbonic anhydrase inhibitor 5 and, most critically, in the treatment of cancer

6. Moreover, due to their advantageous features, acridine compounds are exploited as photoinitiators in laser applications7.

In this study, newly designed coumarin-acridine hybrid compounds, which may have various biological activity potential, were synthesized (not in the literature), and the structural analysis of the compounds was performed by methods such as melting point, FT-IR, 1H-NMR and 13C-NMR.


 

 

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