Palatal Donor-Site Healing and Patient-Reported Outcome Measures Following Chitosan and Injectable Platelet-Rich Fibrin-Enriched Chitosan Application Compared with Gelatine Sponge: A Three-Arm Randomised Controlled Clinical Trial
Journal of Clinical Periodontology, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2026
- Doi Numarası: 10.1111/jcpe.70194
- Dergi Adı: Journal of Clinical Periodontology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE, Academic Search Ultimate (EBSCO), Natural Science Collection (ProQuest), Biological Science Database (ProQuest), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest)
- Anahtar Kelimeler: chitosan, injectable platelet-rich fibrin, pain, palate, wound healing
- Çukurova Üniversitesi Adresli: Evet
Özet
Aim: To compare clinical outcomes and patient-reported outcome measures (PROMs) of palatal donor-site healing following the use of an absorbable gelatine sponge, a chitosan sponge or an injectable platelet-rich fibrin (i-PRF)-enriched chitosan sponge after free gingival graft harvesting. Materials and Methods: In this three-arm randomised controlled clinical study, a total of 68 patients were allocated to three groups: i-PRF + chitosan (n = 22), chitosan (n = 23) and gelatine sponge (control; n = 23). The primary outcome was the palatal early healing index (PEHI). Secondary outcomes included PROMs, namely postoperative pain, burning sensation and changes in dietary habits, which were evaluated using a visual analogue scale (VAS) at postoperative days 7, 14, 28 and 56. Bleeding and painkiller consumption were recorded daily. Colour match was assessed using VAS. Results: Both chitosan-containing groups showed significantly higher PEHI scores, particularly on days 14 and 28, than the control group (p < 0.001). At Day 14, the median PEHI scores were 8.0 (Q1–Q3: 7.0–8.0; 95% CI for the median: 7.0–8.0), 8.0 (Q1–Q3: 8.0–9.0; 95% CI: 8.0–9.0) and 9.0 (Q1–Q3:8.0–9.0; 95% CI: 8.0–9.0) in the control, chitosan and i-PRF-enriched chitosan groups, respectively. The i-PRF + chitosan group showed significantly lower pain and burning sensation during early healing and less changes on dietary habits on days 3 and 7 compared with the other groups (p < 0.05). Bleeding and painkiller consumption were similar among groups (p > 0.05). Both test groups showed significantly better colour match than the control group at days 14, 28 and 56 (p < 0.001). Conclusion: Within the limitations of the present study, chitosan improved early palatal wound healing, while the addition of i-PRF enhanced patient comfort. Both chitosan-containing approaches resulted in improved colour match compared with control. Nevertheless, further studies incorporating histological and biomolecular assessments of wound healing are needed to confirm these findings.