Bivalent and Trivalent Transition Metal Complexes of Azo Compounds Derived from Anthraquinone and Their Mutagenic-Teratogenic Effects


Yildiz E. , Karadeniz B., Yildiz A. M. , Rencuzogullari E.

CHINESE JOURNAL OF INORGANIC CHEMISTRY, vol.29, no.3, pp.595-604, 2013 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.3969/j.issn.1001-4861.2013.00.033
  • Title of Journal : CHINESE JOURNAL OF INORGANIC CHEMISTRY
  • Page Numbers: pp.595-604

Abstract

4-(5'-aminonaphtalene-3'-sulfonic acid)azo-(2 ''-N-(4'", 6'"-dichloro-S-triazine) benzene-5 ''-(beta-sulfatoethyl sulfonyl)-2-methyl anthraquinone (2a), 4-(2'-aminobenzenesulfonic acid)azo-(2 ''-N-(4'", 6'" -dichloro-S-triazine)-3 ''-benzensulfonic acid)-2-methyl anthraquinone, 4-(5'-aminonaphtalene-3'-sulfonic acid)azo-(2 ''-N-(4'", 6'" -dichloro-S-triazine)benzen-5 ''-(beta-sulfatoethyl sulfonyl)-2-methyl anthraquinone and 4-(p-(beta-sulfatoethyl sulfonyl) azo-(2 ''-N-4'", 6'" -dichloro-S-triazine) naphtalene-5 '' sulfonic acid)-2-methyl anthraquinone with Fe-III, Co-II metal complexes were prepared and used for determination of mutagenic and teratogenic effects in Ames/Salmonella/Microsome Test and in embryos of rats. 2a-Fe and 2a-Co were not mutagenic for both TA98 and TA100 strains with and without metabolic activator S9mix.