JOURNAL OF INFECTIOUS DISEASES, vol.218, 2018 (Journal Indexed in SCI)
Article / Article
Title of Journal :
JOURNAL OF INFECTIOUS DISEASES
Ebola virus, protein phosphatase 1, transcription inhibitor, GENERATION
We identified a protein phosphatase 1 (PP1)-targeting compound, C31, that inhibited Ebola virus transcription and replication. C31 bound to the PP1 C-terminal groove and increased VP30 phosphorylation. C31 has better pharmacological properties than 1E7-03 and is a good candidate for future antifiloviral therapy.