Protein Phosphatase 1-Targeting Small-Molecule C31 Inhibits Ebola Virus Replication

Ammosova, YASEMİN; Pietzsch, Colette; Saygideger, Yasemin; Ilatovsky, Andrey; Lin, Xionghao; Ivanov, Andrey; Kumari, Namita; Jerebtsova, Marina; Kulkarni, Amol; Petukhov, Michael; Uren, Aykut; Bukreyev, Alexander; Nekhai, Sergei

doi:10.1093/infdis/jiy422

Protein Phosphatase 1-Targeting Small-Molecule C31 Inhibits Ebola Virus Replication

Ammosova T., Pietzsch C. A., Saygideger Y., Ilatovsky A., Lin X., Ivanov A., ...Daha Fazla

JOURNAL OF INFECTIOUS DISEASES, cilt.218, 2018 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 218
Basım Tarihi: 2018
Doi Numarası: 10.1093/infdis/jiy422
Dergi Adı: JOURNAL OF INFECTIOUS DISEASES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Anahtar Kelimeler: Ebola virus, protein phosphatase 1, transcription inhibitor, GENERATION
Çukurova Üniversitesi Adresli: Evet

Özet

We identified a protein phosphatase 1 (PP1)-targeting compound, C31, that inhibited Ebola virus transcription and replication. C31 bound to the PP1 C-terminal groove and increased VP30 phosphorylation. C31 has better pharmacological properties than 1E7-03 and is a good candidate for future antifiloviral therapy.