Protein Phosphatase 1-Targeting Small-Molecule C31 Inhibits Ebola Virus Replication


Ammosova T. , Pietzsch C. A. , Saygideger Y., Ilatovsky A., Lin X., Ivanov A., ...Daha Fazla

JOURNAL OF INFECTIOUS DISEASES, cilt.218, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 218
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1093/infdis/jiy422
  • Dergi Adı: JOURNAL OF INFECTIOUS DISEASES

Özet

We identified a protein phosphatase 1 (PP1)-targeting compound, C31, that inhibited Ebola virus transcription and replication. C31 bound to the PP1 C-terminal groove and increased VP30 phosphorylation. C31 has better pharmacological properties than 1E7-03 and is a good candidate for future antifiloviral therapy.