Protein Phosphatase 1-Targeting Small-Molecule C31 Inhibits Ebola Virus Replication


Ammosova T. , Pietzsch C. A. , Saygideger Y., Ilatovsky A., Lin X., Ivanov A., ...More

JOURNAL OF INFECTIOUS DISEASES, vol.218, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 218
  • Publication Date: 2018
  • Doi Number: 10.1093/infdis/jiy422
  • Title of Journal : JOURNAL OF INFECTIOUS DISEASES
  • Keywords: Ebola virus, protein phosphatase 1, transcription inhibitor, GENERATION

Abstract

We identified a protein phosphatase 1 (PP1)-targeting compound, C31, that inhibited Ebola virus transcription and replication. C31 bound to the PP1 C-terminal groove and increased VP30 phosphorylation. C31 has better pharmacological properties than 1E7-03 and is a good candidate for future antifiloviral therapy.