The Relaxant Mechanisms of Hydrogen Sulfide in Corpus Cavernosum


AYDINOĞLU F., ÖĞÜLENER N.

VASCULAR EFFECTS OF HYDROGEN SULFIDE: METHODS AND PROTOCOLS, vol.2007, pp.137-150, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 2007
  • Publication Date: 2019
  • Doi Number: 10.1007/978-1-4939-9528-8_10
  • Journal Name: VASCULAR EFFECTS OF HYDROGEN SULFIDE: METHODS AND PROTOCOLS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.137-150
  • Keywords: Corpus cavernosum, Erectile function, Erectile dysfunction, NITRIC-OXIDE, ERECTILE DYSFUNCTION, PENILE ERECTION, NEUROGENIC RELAXATION, RHO-KINASE, IN-VITRO, H2S, MUSCLE, RAT, PHYSIOLOGY
  • Çukurova University Affiliated: Yes

Abstract

In several animal and human studies, the contribution of the endothelium, nitric oxide/soluble guanosine monophosphate (NO/cGMP) pathway, adenylyl cyclase, phosphodiesterase (PDE), potassium(K+) channels, L-type calcium channels, Na+-K+-ATPase, muscarinic acetylcholine receptors, RhoA/Rho-kinase pathway, and cyclooxygenase (COX)/arachidonic acid cascade on the relaxant mechanism of L-cysteine/H2S pathway in corpus cavernosum has been investigated. In this chapter the relaxant mechanisms of H2S in corpus cavernosum is discussed with data available in the current relevant literature. Also, in vitro experimental procedure for mice corpus cavernosum which used to investigate the relaxant effect of H2S is given in detail.