The Relaxant Mechanisms of Hydrogen Sulfide in Corpus Cavernosum

AYDINOĞLU F., ÖĞÜLENER N.

VASCULAR EFFECTS OF HYDROGEN SULFIDE: METHODS AND PROTOCOLS, cilt.2007, ss.137-150, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 2007
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1007/978-1-4939-9528-8_10
  • Dergi Adı: VASCULAR EFFECTS OF HYDROGEN SULFIDE: METHODS AND PROTOCOLS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.137-150
  • Anahtar Kelimeler: Corpus cavernosum, Erectile function, Erectile dysfunction, NITRIC-OXIDE, ERECTILE DYSFUNCTION, PENILE ERECTION, NEUROGENIC RELAXATION, RHO-KINASE, IN-VITRO, H2S, MUSCLE, RAT, PHYSIOLOGY
  • Çukurova Üniversitesi Adresli: Evet

Özet

In several animal and human studies, the contribution of the endothelium, nitric oxide/soluble guanosine monophosphate (NO/cGMP) pathway, adenylyl cyclase, phosphodiesterase (PDE), potassium(K+) channels, L-type calcium channels, Na+-K+-ATPase, muscarinic acetylcholine receptors, RhoA/Rho-kinase pathway, and cyclooxygenase (COX)/arachidonic acid cascade on the relaxant mechanism of L-cysteine/H2S pathway in corpus cavernosum has been investigated. In this chapter the relaxant mechanisms of H2S in corpus cavernosum is discussed with data available in the current relevant literature. Also, in vitro experimental procedure for mice corpus cavernosum which used to investigate the relaxant effect of H2S is given in detail.