Globally, every year, millions of surgical procedures are carried out and most of the patients experience surgical site infections (SSIs) after surgery. This general overview is aimed to find SSI incidence, risk factors, and treatment-related factors in the current scenario of literature searched. Articles from scientific databases such as Google Scholar, Medline, PubMed, and ScienceDirect were searched and extracted with keywords SSI', surgery', surgical infection', wound infection', Risk factors SSI', Antibiotics, and Treatment. The incidence rate of SSIs is on rise in developing countries due to limited reporting which is alarming for patient safety. Various surgery-related guidelines might be helpful in the reduction of SSI incidence. A full assessment of patients before surgery are needed through various available parameters; especially, rational use of antibiotics may minimize the risk of misuse. Healthcare-associated infections need much attention and awareness as the situation is much alarming.