CIRCULATING MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1/CCL-2) AS A POTENTIAL BIOMARKER FOR THE DIAGNOSIS OF PANCREATIC ADENOCARCINOMA


Afsar C. U. , KARABULUT M., Karabulut S., ALIS H., BINBOGA S., Bilgin E., ...Daha Fazla

ACTA MEDICA MEDITERRANEA, cilt.33, ss.501-507, 2017 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 33 Konu: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.19193/0393-6384_2017_3_075
  • Dergi Adı: ACTA MEDICA MEDITERRANEA
  • Sayfa Sayıları: ss.501-507

Özet

Introduction: Pancreatic cancer is a highly lethal malignancy. Chemokines may control the macrophage infiltrate found in many solid tumors. Monocyte chemoattractant protein-1 (MCP-1/CCL2) plays a key role in the recruitment and activation of monocytes during inflammation. MCP-1 is a small chemotactic protein that has been found in several kinds of tumor tissue samples and functions as a key regulator of cancer progression. This study was conducted to investigate the serum levels of MCP-1 in patients with pancreatic adenocarcinoma (PA) and the relationship with tumor progression and known prognostic parameters.