CIRCULATING MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1/CCL-2) AS A POTENTIAL BIOMARKER FOR THE DIAGNOSIS OF PANCREATIC ADENOCARCINOMA

Afsar C. U., KARABULUT M., Karabulut S., ALIS H., BINBOGA S., Bilgin E., ...More

ACTA MEDICA MEDITERRANEA, vol.33, no.3, pp.501-507, 2017 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.19193/0393-6384_2017_3_075
  • Journal Name: ACTA MEDICA MEDITERRANEA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.501-507
  • Çukurova University Affiliated: No

Abstract

Introduction: Pancreatic cancer is a highly lethal malignancy. Chemokines may control the macrophage infiltrate found in many solid tumors. Monocyte chemoattractant protein-1 (MCP-1/CCL2) plays a key role in the recruitment and activation of monocytes during inflammation. MCP-1 is a small chemotactic protein that has been found in several kinds of tumor tissue samples and functions as a key regulator of cancer progression. This study was conducted to investigate the serum levels of MCP-1 in patients with pancreatic adenocarcinoma (PA) and the relationship with tumor progression and known prognostic parameters.