Effects of Intraperitoneally Administered Folic Acid on the Healing of Repaired Tibial Nerves in Rats


HARMA A., Sahin M. S. , ZORLUDEMİR S.

JOURNAL OF RECONSTRUCTIVE MICROSURGERY, vol.31, no.3, pp.191-197, 2015 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 3
  • Publication Date: 2015
  • Doi Number: 10.1055/s-0034-1395414
  • Journal Name: JOURNAL OF RECONSTRUCTIVE MICROSURGERY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.191-197
  • Keywords: folic acid, peripheral nerve, nerve repair, regeneration, CENTRAL-NERVOUS-SYSTEM, TO-SIDE NEURORRHAPHY, AXONAL REGENERATION, FUNCTIONAL RECOVERY, HYALURONIC-ACID, DNA METHYLATION, SUPPLEMENTATION, FOLATE, ADULT

Abstract

Background Complete nerve regeneration and clinical healing remain a challenge despite considerable advances in the treatment of peripheral nerve injuries. To improve nerve regeneration, several experimental molecular procedures have been attempted. This study aimed to investigate the effects of folic acid on peripheral nerve healing after transection and end-to-end suture repair of the tibial nerve in rats.