Strong cross-talk between angiogenesis and EBV: do we need different treatment approaches in lymphoma cases with EBV and/or high angiogenic capacity

Paydas S.

MEDICAL ONCOLOGY, vol.29, no.3, pp.2159-2165, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 29 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.1007/s12032-011-0065-z
  • Journal Name: MEDICAL ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2159-2165
  • Çukurova University Affiliated: Yes

Abstract

Angiogenesis is the new blood vessels formation and is the critical event for the growth of malignant diseases and plays a key role in the development, invasion, and metastasis of malignant tumors. Epstein-Barr virus (EBV) is an important carcinogen causing to the some neoplastic disorders and lytically infected cells may contribute to the growth of EBV-associated malignancies, and this phenomenon is related with enhancing angiogenesis. Due to the strong cross-talk between angiogenesis and viral carcinogenesis and increased information about the angiogenesis and viral carcinogenesis in lymphomas, we need new therapeutic approaches to cases with lymphoma. Due to the strong cross-talk between angiogenesis and viral lymphomagenesis, this association was reviewed in this study.