In this study, an energy and exergy analysis is applied to a ceiling-type air conditioning (CTAC) system operating with various refrigerants. Firstly, the hourly cooling load capacities of a sample building are determined for the months of April, May, June, July, August and September. The cooling load capacity is determined using the hourly analysis program (HAP). Secondly, the coefficient of performance (COP), exergy efficiency and exergy destruction values of the whole system, and each of its components, are determined. Results indicate that the exergy destruction in the compressor, condenser and capillary tube decreases, when refrigerant R600a is used in the CTAC system instead of refrigerant R404A, but the value of exergy destruction in the evaporator does not substantially change. When the refrigerant is changed from R404A to R600a, it is calculated that the power consumption and exergy destruction ratio of the air conditioning system decrease by 13.0 % and 20.2 %, respectively, but the exergy efficiency value is increased by 13.9 %.