Silent pituitary macroadenoma co-secreting growth hormone and thyroid stimulating hormone

Sen O., Ertorer M., Aydin M., Erdogan B., Altinors N., Zorludemir S., ...More

JOURNAL OF CLINICAL NEUROSCIENCE, vol.12, no.3, pp.318-320, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 3
  • Publication Date: 2005
  • Doi Number: 10.1016/j.jocn.2004.05.011
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.318-320
  • Keywords: pituitary adenoma, plurihormonal, silent, INSITU HYBRIDIZATION, ADENOMAS, TUMORS, GALACTORRHEA, ENDOCRINE, REMOVAL, TURKEY
  • Çukurova University Affiliated: Yes


Silent pituitary adenomas are a group of tumors showing heterogenous morphological features with no hormonal function observed clinically. To date no explanation has been provided as to why these tumors remain "silent". We report a case of a silent macroadenoma. with both growth hormone (GH) and thyroid stimulating hormone (TSH) staining and secretion but with no clinical manifestations, in particular, the absence of features of acromegaly or hyperthyroidism. The relevant literature is reviewed. (c) 2004 Elsevier Ltd. All rights reserved.