Prognostic value of neutrophil-to-lymphocyte ratio in patients undergoing curative surgical resection for hepatocellular carcinoma

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Sarıtaş A. G. , Ülkü A. , Topal U., Dalcı K. , Eray İ. C. , Akçam A. T.

Annals of Medical Research, vol.27, no.11, pp.2926, 2020 (Refereed Journals of Other Institutions)

  • Publication Type: Article / Article
  • Volume: 27 Issue: 11
  • Publication Date: 2020
  • Title of Journal : Annals of Medical Research
  • Page Numbers: pp.2926



Aim: the purpose of this study is to determine the prognostic value of the preoperative Neutrophil-to-Lymphocyte ratio (NLR) in

patients who underwent curative surgical treatment for hepatocellular carcinoma (HCC).

Materials and Methods: Patients who underwent curative resection for HCC between 2004 and 2015 were included in the study.

Patients were divided into two groups based on the cut-off value: Group 1 (NLR low) and Group 2 (NLR elevated). Demographics and

clinical characteristics, tumor characteristics, and mean survival of patients were compared between the groups.

Results: 41 patients were included in our study and Group 1 (NLR low) consisted of (n:11) patients; Group 2 (NLR elevated) consisted

of (n:30) patients based on a cut-off value of 2.43. The number of males was higher in both groups (90.9% vs 90%, p:0.712). The

Child-Plug class A was the most common one in both groups (81.8%vs76.7%, p:0.680). HBV infection was the most common

etiological cause (81.8% vs 53.3%, p:0.344). Lesions were predominantly located in the right lobe (63.6% vs 66.7%, p:0.568). The total

tumor diameter was similar (6.56 cm vs 8.69 cm, p:0.258). In the multivariate analysis for survival, tumor diameter greater than 5

cm (HR 1.412 95% - Cl0.345-5.780, p:0.018) and NLR higher than 2.43 (HR 0.100 95% -Cl 0.011-0.882, p:0.038) were independent

risk factors. Overall survival time was found to be lower in Group 2 compared to Group 1 (171 vs 106 months p:0.033). Disease-free

survival rates were similar in the groups (37 vs 43 months, p:0.485).

Conclusion: Although the elevated NLR level was found to be a risk factor for decreased overall survival in our study, this was not

related to clinicopathological variables.

Keywords: Hepatocellular carcinoma; Neutrophil-to-lymphocyte ratio; surgical resection; prognosis.