The effect of cryotreated sodium hypochlorite irrigation at different concentrations on postoperative pain in mandibular first molars with symptomatic irreversible pulpitis: a randomized controlled clinical trial
BMC Oral Health, cilt.25, sa.1, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 25 Sayı: 1
- Basım Tarihi: 2025
- Doi Numarası: 10.1186/s12903-025-07410-3
- Dergi Adı: BMC Oral Health
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, MEDLINE, Directory of Open Access Journals
- Anahtar Kelimeler: Cryotherapy, Irreversible pulpitis, Postoperative pain, Root canal treatment, Sodium hypochlorite
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Çukurova Üniversitesi Adresli: Evet
Özet
Background: The purpose of this study was to evaluate the effects of cryotreated 2.5% and 5% sodium hypochlorite (NaOCl) on postoperative pain during endodontic treatment procedures in mandibular first molars with symptomatic irreversible pulpitis. Methods: One hundred and thirty two patients with permanent mandibular first molars diagnosed with symptomatic irreversible pulpitis were included in the study. The teeth were randomly divided into four groups: the normal 2.5% NaOCl group (n = 33), the cryotreated 2.5% NaOCl group (n = 33), the normal 5% NaOCl group (n = 33) and the cryotreated 5% NaOCl group (n = 33). In the normal NaOCl groups, the root canals were irrigated with NaOCl solution at 25 °C at all stages of the root canal treatment. In the cryotreated NaOCl groups, the root canals were irrigated with NaOCl solution at 2 °C at all stages of the root canal treatment. The participants were asked to rate the intensity of their postoperative pain via a Visual Analog Scale (VAS) at 6 h, 12 h, 24 h, 48 h, and 72 h. The data were analyzed using the Shapiro-Wilk, Levene’s, Kruskal Wallis H and the Chi-square test. Results: The basic demographic data, preoperative pain values and analgesic intake of the four study groups were similar. Postoperative pain levels at 6 h were significantly lower in the cryotreated 2.5% NaOCl group than in all the other groups (p <.05). Postoperative pain levels at 12 h were statistically similar between the cryotreated 2.5% NaOCl group and the cryotreated 5% NaOCl group (p >.05) and significantly lower than those in the other two groups (p <.05). Conclusions: Using cryotreated NaOCl irrigation at different concentrations during root canal treatment procedures in mandibular first molars with symptomatic irreversible pulpitis effectively reduced postoperative pain. Trial registration: This study was registered at ClinicalTrials.gov (NCT06820996) on 11 February 2025.