Discontinuation of RAAS Inhibition in Children with Advanced CKD


van den Belt S. M. , Heerspink H. J. L. , Kirchner M., Gracchi V., Thurn-Valsassina D., Bayazit A. , ...More

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol.15, no.5, pp.625-632, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 5
  • Publication Date: 2020
  • Doi Number: 10.2215/cjn.09750819
  • Title of Journal : CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
  • Page Numbers: pp.625-632

Abstract

Background and objectives Although renin-angiotensin-aldosterone system inhibition (RAASi) is a cornerstone in the treatment of children with CKD, it is sometimes discontinued when kidney function declines. We studied the reasons of RAASi discontinuation and associations between RAASi discontinuation and important risk markers of CKD progression and on eGFR decline in the Cardiovascular Comorbidity in Children with CKD study.