CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, vol.53, pp.32-39, 1989 (Journal Indexed in SCI Expanded)
forms of homozygous sickle cell disease (SCD) were compared with those of healthy
control subjects. Random neutrophil migration, chemotactic activity, and lymphocyte
transformation index were all defective in individuals with severe variants of SCD when
compared with individuals with mild disease or healthy controls. In contrast, serum
opsonization activity was significantly reduced in both severe and mild variants of SCD.
There were no statistical differences between serum immunoglobulin (IgA. IgG, and
IgM) or complement C3 levels in any of the three groups. These results demonstrate that
even though individuals with the mild variant of SCD possess two S genes, their immune
functions are generally normal and in parallel with their clinical and hematological status.
The one area of impaired immune function is their defective serum opsonization activity
and this may explain their sensitivity to certain infections. Cl 1989 Academtc Press. Inc.