Role of ROCK upregulation in endothelial and smooth muscle vascular functions in diabetic rat aorta


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Cicek F. A. , Kandilci H. B. , Turan B.

CARDIOVASCULAR DIABETOLOGY, vol.12, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12
  • Publication Date: 2013
  • Doi Number: 10.1186/1475-2840-12-51
  • Title of Journal : CARDIOVASCULAR DIABETOLOGY

Abstract

Background: The RhoA/ROCK signaling pathway mediates vascular smooth muscle contraction while endogenous NO induces vasodilation through its inhibition. Since myosin light chain phosphatase (MLCP) and eNOS are targeted by RhoA/ROCK upregulation then turn to lead abnormalities in vasculature, we aimed to examine whether less endothelial NO-production and inhibited eNOS together with an upregulation of RhoA/ROCK signaling pathway in thoracic aorta can play an important role in vascular dysfunction under hyperglycemia.