Role of ROCK upregulation in endothelial and smooth muscle vascular functions in diabetic rat aorta

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Cicek F. A., Kandilci H. B., Turan B.

CARDIOVASCULAR DIABETOLOGY, vol.12, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12
  • Publication Date: 2013
  • Doi Number: 10.1186/1475-2840-12-51
  • Journal Name: CARDIOVASCULAR DIABETOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Vessel function, Nitric oxide, Diabetes, eNOS, ROCK pathway, RHOA/RHO-KINASE PATHWAY, RHO-KINASE, NITRIC-OXIDE, MYOSIN PHOSPHATASE, CARDIOVASCULAR-DISEASES, OXIDATIVE STRESS, DYSFUNCTION, PHOSPHORYLATION, INHIBITION, CELLS
  • Çukurova University Affiliated: No

Abstract

Background: The RhoA/ROCK signaling pathway mediates vascular smooth muscle contraction while endogenous NO induces vasodilation through its inhibition. Since myosin light chain phosphatase (MLCP) and eNOS are targeted by RhoA/ROCK upregulation then turn to lead abnormalities in vasculature, we aimed to examine whether less endothelial NO-production and inhibited eNOS together with an upregulation of RhoA/ROCK signaling pathway in thoracic aorta can play an important role in vascular dysfunction under hyperglycemia.