CHK2 1100delC, IVS2+1G > A and I157T mutations are not present in hepatocellular cancer cases from a Turkish population

Bayram S., Akkiz H., TOPAKTAŞ M.

GENE, vol.512, no.2, pp.232-236, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 512 Issue: 2
  • Publication Date: 2013
  • Doi Number: 10.1016/j.gene.2012.10.045
  • Journal Name: GENE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.232-236
  • Çukurova University Affiliated: Yes

Abstract

Aim: The cell cycle checkpoint kinase 2 (CHK2) protein participates in the DNA damage response in many cell types. Germline mutations in CHK2 (1100delC, IVS2 + 1G>A and I157T) have been associated with a range of cancer types. This study aimed to investigate whether CHK2 1100delC, IVS2 + 1G>A and I157T mutations play an important role in the development of hepatocellular carcinoma (HCC) in a Turkish population.