CHK2 1100delC, IVS2+1G > A and I157T mutations are not present in hepatocellular cancer cases from a Turkish population

Bayram, Suleyman; Akkiz, HİKMET; TOPAKTAŞ, MEHMET

doi:10.1016/j.gene.2012.10.045

CHK2 1100delC, IVS2+1G > A and I157T mutations are not present in hepatocellular cancer cases from a Turkish population

Bayram S., Akkiz H., TOPAKTAŞ M.

GENE, cilt.512, sa.2, ss.232-236, 2013 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 512 Sayı: 2
Basım Tarihi: 2013
Doi Numarası: 10.1016/j.gene.2012.10.045
Dergi Adı: GENE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.232-236
Çukurova Üniversitesi Adresli: Evet

Özet

Aim: The cell cycle checkpoint kinase 2 (CHK2) protein participates in the DNA damage response in many cell types. Germline mutations in CHK2 (1100delC, IVS2 + 1G>A and I157T) have been associated with a range of cancer types. This study aimed to investigate whether CHK2 1100delC, IVS2 + 1G>A and I157T mutations play an important role in the development of hepatocellular carcinoma (HCC) in a Turkish population.