CHK2 1100delC, IVS2+1G > A and I157T mutations are not present in hepatocellular cancer cases from a Turkish population

Bayram S., Akkiz H. , TOPAKTAŞ M.

GENE, cilt.512, ss.232-236, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 512 Konu: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.gene.2012.10.045
  • Dergi Adı: GENE
  • Sayfa Sayıları: ss.232-236


Aim: The cell cycle checkpoint kinase 2 (CHK2) protein participates in the DNA damage response in many cell types. Germline mutations in CHK2 (1100delC, IVS2 + 1G>A and I157T) have been associated with a range of cancer types. This study aimed to investigate whether CHK2 1100delC, IVS2 + 1G>A and I157T mutations play an important role in the development of hepatocellular carcinoma (HCC) in a Turkish population.