Maternal polymorphisms of MTHFR gene and risk of Down syndrome offspring in Turkish population


Keser N., PAZARBAŞI A. , ÖZPAK L.

CUKUROVA MEDICAL JOURNAL, vol.43, no.1, pp.73-80, 2018 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.17826/cumj.340356
  • Title of Journal : CUKUROVA MEDICAL JOURNAL
  • Page Numbers: pp.73-80

Abstract

Purpose: The aim of this study was to determine the allele frequencies and genotype distributions of MTHFR (methylenetetrahydrofolate reductase) gene C677T and A1298C polymorphisms and investigate the relationship between these genotypes and folate and homocysteine levels for mothers that having children with down syndrome.