Effect of Botulinum Toxin Type A on Mandibular Fracture Healing: An Experimental Study in Rabbits.


Creative Commons License

Tukel H. C. , Daglioglu Y. K. , Tatli U., Gundogdu L. S. , Kurkcu M., Benlidayi M. E.

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, cilt.78, 2020 (SCI Expanded İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 78
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.joms.2020.06.001
  • Dergi Adı: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

Özet

PURPOSE:

The effect of botulinum toxin type A (BTX-A) on fracture healing of the long bones is controversial, and no controlled clinical or experimental study has investigated the effect of BTX-A on mandibular fractures. The purpose of this study was to investigate whether BTX-A injection into the masseter muscles affects bone healing by reducing the displacing forces in an unfavorable mandibular fracture model. 

MATERIALS AND METHODS:

Forty-eight male New Zealand white rabbits were used. Ten units of BTX-A was injected into each masseter muscle in the animals in the BTX-A group, whereas saline solution was injected in the animals in the control group. A unilateral osteotomy and fixation with a microplate were performed. Bone healing was evaluated by radiodensitometric, biomechanical, histologic, and histomorphometric methods after 21 days. 

RESULTS:

The mean bone mineral density in the fracture area was significantly higher in the BTX-A group (P=. 038). The mean failure load and bending modulus values were significantly higher in the BTX-A group than in the control group (P=. 032 and P=. 005, respectively). The mean histologic bone healing scores, bone volume-total volume values, and trabecular diameter values were significantly higher in the BTX-A group than in the control group (P=. 001, P=. 001, and P=. 026, respectively). 

CONCLUSIONS:

BTX-A application into the masseter muscles improves bone healing of a unilateral mandibular fracture in rabbits.