Could nephrotoxicity due to colistin be ameliorated with the use of N-acetylcysteine?

ÖZYILMAZ E., Ebinc F. A., DERİCİ Ü., GÜLBAHAR Ö., Goktas G., ELMAS Ç., ...More

INTENSIVE CARE MEDICINE, vol.37, no.1, pp.141-146, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 1
  • Publication Date: 2011
  • Doi Number: 10.1007/s00134-010-2038-7
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.141-146
  • Keywords: Colistin, Nephrotoxicity, N-Acetylcysteine (NAC), Oxidative stress, i-NOS, NT-3, ACUTE-RENAL-FAILURE, INTRAVENOUS COLISTIN, ACETYL CYSTEINE, POLYMYXIN-B, PREVENTION
  • Çukurova University Affiliated: Yes


The protective effect of N-acetylcysteine (NAC) on nephrotoxicity due to contrast nephropathy and reperfusion-induced ischemia has been reported in experimental models. However, its efficacy on colistin-induced nephrotoxicity has not been elucidated yet. The primary aim of this study was to evaluate the nephrotoxic effect of colistin and to investigate the possible protective effect of NAC on colistin-induced nephrotoxicity. The secondary aim was to research the systemic effects of nephrotoxicity-induced oxidative stress on the lung.