EFFECT OF MDA LEVEL ON G6PD ACTIVITY AND MEMBRANE PROTEINS CHANGES IN ANEMIC CASES

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Ariyurek S. Y., Yildiz S. M., Aksoy K.

ACTA MEDICA MEDITERRANEA, cilt.32, sa.2, ss.367-372, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.19193/0393-6384_2016_2_55
  • Dergi Adı: ACTA MEDICA MEDITERRANEA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.367-372
  • Çukurova Üniversitesi Adresli: Evet

Özet

Introduction: Glucose 6-phosphate dehydrogenase (G6PD) is the first and rate restricting enzyme in the hexose monophosphate shunt. Malondialdehyde (MDA) generated through decomposition of peroxided lipids influences the intrinsic mechanical properties of the red blood cell (RBC) membrane, which leads to reduced deformability. In this study we investigated effect of MDA on G6PD activity and membrane protein abnormalities in vitro.