Biological Activities and Drug-Likeness Properties of Phenol-Based Heterocyclic Compounds

YAMALI C., NENNİ M., Sakarya M. T., Sakagami H., GÜL H. İ.

Pharmaceutical Chemistry Journal, 2024 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Publication Date: 2024
  • Doi Number: 10.1007/s11094-024-03076-3
  • Journal Name: Pharmaceutical Chemistry Journal
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core
  • Keywords: anticancer, antioxidant, cytotoxicity, drug-likeness, phenol, SwissADME
  • Çukurova University Affiliated: Yes


The widespread use of small molecules having heterocyclic rings to design anticancer agents, and the antioxidant potential of their phenolic conjugates led us to investigate phenol-based heterocyclic compounds’ anticancer, antioxidant activities, and drug-likeness properties. While compounds were evaluated in regards to cancer and non-cancer cell lines by the MTT method, antioxidant effects were carried out using the DPPH method. Drug-likeness properties were also evaluated using SwissADME software. The mean CC50 values were in the range 18.7 – >400 μM toward carcinoma cell lines. Compound 2-(benzo[d]thiazol-2-ylthio)-1-(4-hydroxyphenyl)ethanone showed the highest selectivity cytotoxicity and it showed antioxidant effect with IC50 = 0.036 ± 0.004 mg/mL. All compounds generally showed promising pharmacokinetic behaviors by obeying the various drug-likeness approaches.