Zebrafish as a model organism in probiotic and postbiotic research for aquaculture
3 rd International Marine & Freshwater Sciences Symposium, Hatay, Türkiye, 1 - 02 Eylül 2026, ss.106-132, (Tam Metin Bildiri)
- Yayın Türü: Bildiri / Tam Metin Bildiri
- Basıldığı Şehir: Hatay
- Basıldığı Ülke: Türkiye
- Sayfa Sayıları: ss.106-132
- Çukurova Üniversitesi Adresli: Evet
Özet
In aquaculture, the control of infectious disease and the maintenance of fish health are addressedthrough both therapeutic and preventive approaches. Because antimicrobial use can lead toresistance and to residue accumulation in farmed fish, probiotics and, more recently, postbioticsform an expanding area of aquaculture research that addresses growth performance, intestinalhistology, microbiota composition and immune-related gene expression in fish. Zebrafish are
inexpensive to maintain, develop rapidly and have a short generation time, and germ-free andgnotobiotic conditions can be used to examine host–microbiota interactions. This reviewexamines the use of zebrafish (Danio rerio) as a model organism for investigating the
mechanistic responses to probiotics and postbiotics, covering immune and inflammatoryregulation, oxidative stress and antioxidant defence, intestinal barrier integrity andhistomorphology, gut microbiota composition, pathogen resistance, growth and reproduction.The extent to which findings obtained in zebrafish can be applied to aquaculture species is alsodiscussed, in view of the differences reported between zebrafish and farmed fish and between
laboratory and farm conditions. Further studies are needed to characterise dose–response
relationships, compare live and inactivated forms of the same strain, and examine pathogensother than the Aeromonas species used in most challenge studies to date. The potential use of
preparations that give consistent responses in zebrafish could then be assessed in target farmed
species.