Relation of serum spondin-2 levels with cardiac morphology and inflammatory parameters in hemodialysis patients
INTERNATIONAL UROLOGY AND NEPHROLOGY, cilt.50, sa.11, ss.2091-2097, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 50 Sayı: 11
- Basım Tarihi: 2018
- Doi Numarası: 10.1007/s11255-018-1996-5
- Dergi Adı: INTERNATIONAL UROLOGY AND NEPHROLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.2091-2097
- Anahtar Kelimeler: Chronic kidney disease, Echocardiography, Endothelial dysfunction, Inflammation, Spondin-2, DIABETIC-NEPHROPATHY, MINDIN, HYPERTROPHY, INJURY, MARKER, TARGET
- Çukurova Üniversitesi Adresli: Hayır
Özet
PurposeCardiovascular diseases are the leading causes of mortality in chronic kidney disease. Spondin-2 (SP-2), an intrinsic cardio-protective factor, prevents maladaptive remodeling. We aimed to determine the relation between serum SP-2 levels and cardiac morphology along with inflammatory parameters in hemodialysis (HD) patients.MethodThe study comprised a total of 95 patients (61 females) receiving HD treatment three times a week for at least 6months, and a control group consisting of age and gender matched 62 subjects (34 females). SP-2 levels were determined by ELISA. Echocardiography, 24-h ambulatory blood pressure monitoring, and carotid artery intima-media thickness (CIMT) measurement were performed in all subjects. The relation of serum SP-2 levels with CIMT, echocardiographic parameters, CRP, and absolute neutrophil-to-lymphocyte count ratio (NLR) was evaluated by correlation analysis.ResultsSP-2 levels were found to be significantly higher in the HD group than the control group (16.660 [8.719-20.938] vs. 3.988 [2.702-8.042] ng/L; P<0.001). CIMT, CRP, and NLR were also higher in HD group (P<0.005, P<0.001, and P<0.001, respectively). Significantly positive correlation was found between SP-2 and left ventricular mass, left ventricular mass index, CRP, and NLR, but no correlation was determined between SP-2 and CIMT. SP-2 was not statistically significant variable for the determination of LVH in univariate logistic regression analysis [Wald=2.375; OR (95% CI)=1.000 (0.999-1.000), P=0.123].ConclusionSerum SP-2 levels were higher in HD patients compared to the population with normal renal functions. The results suggest that SP-2, an uremic toxin, might be effective over a complex pathway in the inflammatory process and in the pathogenesis of cardiovascular diseases of patients under HD treatment.