Secondary Lymphoma in a Patient with a History of Unilateral Retinoblastoma


KOZANOGLU B., SEZGİN G. , BAGIR E., ÖZKAN A., BAYRAM İ. , TANYELİ A., ...More

CUKUROVA MEDICAL JOURNAL, vol.40, pp.33-37, 2015 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 40
  • Publication Date: 2015
  • Title of Journal : CUKUROVA MEDICAL JOURNAL
  • Page Numbers: pp.33-37

Abstract

Second malignancies develop with increased incidence in patients with herediter retinoblastoma. The most common second malignancies in retinoblastoma survivors are soft tissue sarcoma and osteosarcoma. Lymphoma developing as a second malignancy has rarely been reported. Here we report a case of lymphoma diagnosed in a 13 year-old-boy, 12 years after the diagnosis of unilateral retinoblastoma having heterozygous p.R552 (c.1654C>T) mutation, treated with enucleation and radiotherapy. The risk of second tumour is higher in the hereditary retinoblastoma, especially in cases undergoing external beam radiation therapy.