GLUT-1 Expression in Proliferative Endometrium, Endometrial Hyperplasia, Endometrial Adenocarcinoma and the Relationship Between GLUT-1 Expression and Prognostic Parameters in Endometrial Adenocarcinoma

Canpolat, Tuba; Ersoz, Canan; Uguz, Aysun; VARDAR, MEHMET; Altintas, Aytekin

doi:10.5146/tjpath.2015.01352

GLUT-1 Expression in Proliferative Endometrium, Endometrial Hyperplasia, Endometrial Adenocarcinoma and the Relationship Between GLUT-1 Expression and Prognostic Parameters in Endometrial Adenocarcinoma

Canpolat T., Ersoz C., Uguz A., VARDAR M. A., Altintas A.

TURKISH JOURNAL OF PATHOLOGY, cilt.32, sa.3, ss.141-147, 2016 (ESCI, Scopus, TRDizin)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 32 Sayı: 3
Basım Tarihi: 2016
Doi Numarası: 10.5146/tjpath.2015.01352
Dergi Adı: TURKISH JOURNAL OF PATHOLOGY
Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.141-147
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Çukurova Üniversitesi Adresli: Evet

Özet

Objective: Malignant cells show increased glucose uptake in in vitro and in vivo studies. This uptake is mediated by glucose transporter proteins. GLUT-1 is the most common transporter protein, and its expression is reported to be increase in many human cancers. The aim of this study is to determine the GLUT-1 overexpression in benign, hyperplastic, and malignant endometrial tissues, to evaluate the usefulness of GLUT-1 expression in endometrial hyperplasia, and to determine its role in the neoplastic progression to endometrioid type adenocarcinoma. We also aimed to analyze prognostic clinical parameters, predict prognosis, and survival.