The effects of some K+ channel blockers on scopolamine- or electroconvulsive shock-induced amnesia in mice


INAN S., Aksu F. , BAYSAL F.

EUROPEAN JOURNAL OF PHARMACOLOGY, cilt.407, ss.159-164, 2000 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 407
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1016/s0014-2999(00)00736-6
  • Dergi Adı: EUROPEAN JOURNAL OF PHARMACOLOGY
  • Sayfa Sayıları: ss.159-164

Özet

The effects of three K+ channel blockers, 4-aminopyridine, 3,4-diaminopyridine and apamin, on scopolamine- or electroconvulsive shock-induced amnesia were investigated in mice by using a one-trial step-down passive avoidance system. Scopolamine and electroconvulsive shuck reduced the retention latency of passive avoidance, which indicated the amnestic effect of these treatments. 4-Aminopyridine, 3,4-diaminopyridine and apamin injected immediately after the acquisition trial, reversed the amnestic effect of scopolamine or electroconvulsive shuck in a dose-dependent manner. None of the drugs or electroconvulsive shock treatment affected the rotarod or activity cage performance of the mice. These results indicate that K+ channel blockers may improve cognitive deficits when memory is impaired by a drug or any other manipulation. (C) 2000 Elsevier Science B.V. All rights reserved.