The effects of some K+ channel blockers on scopolamine- or electroconvulsive shock-induced amnesia in mice

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INAN S., Aksu F., BAYSAL F.

EUROPEAN JOURNAL OF PHARMACOLOGY, vol.407, pp.159-164, 2000 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 407
• Publication Date: 2000
• Doi Number: 10.1016/s0014-2999(00)00736-6
• Journal Name: EUROPEAN JOURNAL OF PHARMACOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.159-164
• Çukurova University Affiliated: Yes

Abstract

The effects of three K+ channel blockers, 4-aminopyridine, 3,4-diaminopyridine and apamin, on scopolamine- or electroconvulsive shock-induced amnesia were investigated in mice by using a one-trial step-down passive avoidance system. Scopolamine and electroconvulsive shuck reduced the retention latency of passive avoidance, which indicated the amnestic effect of these treatments. 4-Aminopyridine, 3,4-diaminopyridine and apamin injected immediately after the acquisition trial, reversed the amnestic effect of scopolamine or electroconvulsive shuck in a dose-dependent manner. None of the drugs or electroconvulsive shock treatment affected the rotarod or activity cage performance of the mice. These results indicate that K+ channel blockers may improve cognitive deficits when memory is impaired by a drug or any other manipulation. (C) 2000 Elsevier Science B.V. All rights reserved.