Increased oxidative stress and oxidative DNA damage in non-remission schizophrenia patients

Copoglu U. S., Virit O., Kokacya M. H., Orkmez M., Bulbul F., Erbagci A. B., ...More

PSYCHIATRY RESEARCH, vol.229, pp.200-205, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 229
  • Publication Date: 2015
  • Doi Number: 10.1016/j.psychres.2015.07.036
  • Journal Name: PSYCHIATRY RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.200-205
  • Çukurova University Affiliated: No

Abstract

Increasing evidence shows that oxidative stress plays a role in the pathophysiology of schizophrenia. But there is not any study which examines the effects of oxidative stress on DNA in schizophrenia patients. Therefore we aimed to assess the oxidative stress levels and oxidative DNA damage in schizophrenia patients with and without symptomatic remission. A total of 64 schizophrenia patients (38 with symptomatic remission and 26 without symptomatic remission) and 80 healthy volunteers were included in the study. 8-hydroxydeoxyguanosine (8-OHdG), total oxidant status (TOS) and total antioxidant status (TAS) were measured in plasma.