Increased oxidative stress and oxidative DNA damage in non-remission schizophrenia patients

Copoglu, U.; Virit, Osman; Kokacya, M.; Orkmez, Mustafa; Bulbul, FERİDUN; Erbagci, A.; Semiz, Murat; Alpak, Gokay; Unal, Ahmet; Ari, Mustafa; Savas, Haluk

doi:10.1016/j.psychres.2015.07.036

Increased oxidative stress and oxidative DNA damage in non-remission schizophrenia patients

Atıf İçin Kopyala

Copoglu U. S., Virit O., Kokacya M. H., Orkmez M., Bulbul F., Erbagci A. B., ...Daha Fazla

PSYCHIATRY RESEARCH, cilt.229, ss.200-205, 2015 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 229
Basım Tarihi: 2015
Doi Numarası: 10.1016/j.psychres.2015.07.036
Dergi Adı: PSYCHIATRY RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
Sayfa Sayıları: ss.200-205
Çukurova Üniversitesi Adresli: Hayır

Özet

Increasing evidence shows that oxidative stress plays a role in the pathophysiology of schizophrenia. But there is not any study which examines the effects of oxidative stress on DNA in schizophrenia patients. Therefore we aimed to assess the oxidative stress levels and oxidative DNA damage in schizophrenia patients with and without symptomatic remission. A total of 64 schizophrenia patients (38 with symptomatic remission and 26 without symptomatic remission) and 80 healthy volunteers were included in the study. 8-hydroxydeoxyguanosine (8-OHdG), total oxidant status (TOS) and total antioxidant status (TAS) were measured in plasma.