Prognostic significance of EBV-LMP1 and VEGF-A expressions in non-Hodgkin's lymphomas


PAYDAŞ S. , ERGİN M. , ERDOĞAN Ş. , SEYDAOĞLU G.

LEUKEMIA RESEARCH, vol.32, no.9, pp.1424-1430, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 9
  • Publication Date: 2008
  • Doi Number: 10.1016/j.leukres.2008.01.008
  • Title of Journal : LEUKEMIA RESEARCH
  • Page Numbers: pp.1424-1430
  • Keywords: VEGF-A, EBV, NHL, prognosis, angiogenesis, viral lymphangiogenesis, EPSTEIN-BARR-VIRUS, ENDOTHELIAL GROWTH-FACTOR, LATENT MEMBRANE PROTEIN-1, B-CELL LYMPHOMA, MICROVESSEL DENSITY, ANGIOGENESIS, DISEASE, PREVALENCE, RECEPTORS, INFECTION

Abstract

Background and aim: EBV is an important virus in the pathogenesis of NHL. VEGF-A is the essential factor in tumor angiogenesis. There is evidence of cross talk between angiogenesis and viral carcinogenesis. The viral latent protein LMP1, may play a role by inducing expression of angiogenic factors In this study EBV-LMP1 and VEGF-A expressions have been studied in cases with NHL and prognostic significance of these has been evaluated.