Maspin overexpression correlates with increased expression of vascular endothelial growth factors A, C, and D in human ovarian carcinoma


BOLAT F., GÜMÜRDÜLÜ D. , Erkanli S., KAYASELÇUK F., Zeren H., VARDAR M. A. , ...More

PATHOLOGY RESEARCH AND PRACTICE, vol.204, no.6, pp.379-387, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 204 Issue: 6
  • Publication Date: 2008
  • Doi Number: 10.1016/j.prp.2008.01.011
  • Title of Journal : PATHOLOGY RESEARCH AND PRACTICE
  • Page Numbers: pp.379-387

Abstract

The vascular endothelial growth factor (VEGF) family, including VEGFA, VEGFC, and VEGFD, plays an essential role in the angiogenesis of both pathologic and nonpathologic conditions. Maspin belongs to the serpin superfamily and has been identified as a tumor suppressor because it inhibits motility, invasion, and angiogenesis. Few studies have compared maspin with VEGF in ovarian carcinoma. Therefore, we investigated the expression and correlation of maspin, VEGFA, VEGFC, and VEGFD with the tumorigenesis of the ovary and clinicopathologic variables.