Maspin overexpression correlates with increased expression of vascular endothelial growth factors A, C, and D in human ovarian carcinoma

BOLAT F., GÜMÜRDÜLÜ D. , Erkanli S., KAYASELÇUK F., Zeren H., VARDAR M. A. , ...Daha Fazla

PATHOLOGY RESEARCH AND PRACTICE, cilt.204, ss.379-387, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 204 Konu: 6
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.prp.2008.01.011
  • Sayfa Sayıları: ss.379-387


The vascular endothelial growth factor (VEGF) family, including VEGFA, VEGFC, and VEGFD, plays an essential role in the angiogenesis of both pathologic and nonpathologic conditions. Maspin belongs to the serpin superfamily and has been identified as a tumor suppressor because it inhibits motility, invasion, and angiogenesis. Few studies have compared maspin with VEGF in ovarian carcinoma. Therefore, we investigated the expression and correlation of maspin, VEGFA, VEGFC, and VEGFD with the tumorigenesis of the ovary and clinicopathologic variables.