Effects of selective Cox-2 inhibitor, rofecoxib, alone or combination with furosemide on renal functions and renal Cox-2 expression in rats

Kose F., Besen A., Paydaş S., Balal M., Gönlüşen G., Inal T., ...Daha Fazla

CLINICAL AND EXPERIMENTAL NEPHROLOGY, cilt.14, ss.22-27, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1007/s10157-009-0214-2
  • Dergi Adı: CLINICAL AND EXPERIMENTAL NEPHROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.22-27
  • Çukurova Üniversitesi Adresli: Evet

Özet

Nonsteroidal anti-inflammatory drugs act by inhibiting the rate-limiting enzymes cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2), which are important in prostanoid formation. The aim of this experimental study was to examine the effects of selective Cox-2 inhibitor, rofecoxib, with or without furosemide, on urine and serum electrolytes, creatinine clearance, plasma renin activity (PRA), and Cox-2 expression in the renal cortex.