Effects of selective Cox-2 inhibitor, rofecoxib, alone or combination with furosemide on renal functions and renal Cox-2 expression in rats


Kose F., Besen A., Paydaş S. , Balal M. , Gönlüşen G. , Inal T., ...More

CLINICAL AND EXPERIMENTAL NEPHROLOGY, vol.14, pp.22-27, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14
  • Publication Date: 2010
  • Doi Number: 10.1007/s10157-009-0214-2
  • Title of Journal : CLINICAL AND EXPERIMENTAL NEPHROLOGY
  • Page Numbers: pp.22-27

Abstract

Nonsteroidal anti-inflammatory drugs act by inhibiting the rate-limiting enzymes cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2), which are important in prostanoid formation. The aim of this experimental study was to examine the effects of selective Cox-2 inhibitor, rofecoxib, with or without furosemide, on urine and serum electrolytes, creatinine clearance, plasma renin activity (PRA), and Cox-2 expression in the renal cortex.