Effects of selective Cox-2 inhibitor, rofecoxib, alone or combination with furosemide on renal functions and renal Cox-2 expression in rats

Kose, Fatih; Besen, Ayberk; Paydaş, SAİME; Balal, MUSTAFA; Gönlüşen, GÜLFİLİZ; Inal, Tamer; Doğan, AYŞE; Kibar, MUSTAFA

doi:10.1007/s10157-009-0214-2

Effects of selective Cox-2 inhibitor, rofecoxib, alone or combination with furosemide on renal functions and renal Cox-2 expression in rats

Kose F., Besen A., Paydaş S. , Balal M. , Gönlüşen G. , Inal T., ...More

CLINICAL AND EXPERIMENTAL NEPHROLOGY, vol.14, pp.22-27, 2010 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 14
Publication Date: 2010
Doi Number: 10.1007/s10157-009-0214-2
Title of Journal : CLINICAL AND EXPERIMENTAL NEPHROLOGY
Page Numbers: pp.22-27

Abstract

Nonsteroidal anti-inflammatory drugs act by inhibiting the rate-limiting enzymes cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2), which are important in prostanoid formation. The aim of this experimental study was to examine the effects of selective Cox-2 inhibitor, rofecoxib, with or without furosemide, on urine and serum electrolytes, creatinine clearance, plasma renin activity (PRA), and Cox-2 expression in the renal cortex.