Effects of selective Cox-2 inhibitor, rofecoxib, alone or combination with furosemide on renal functions and renal Cox-2 expression in rats

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Atıf İçin Kopyala

Kose F., Besen A., Paydaş S. , Balal M. , Gönlüşen G. , Inal T., ...Daha Fazla

CLINICAL AND EXPERIMENTAL NEPHROLOGY, cilt.14, ss.22-27, 2010 (SCI İndekslerine Giren Dergi)

• Cilt numarası: 14
• Basım Tarihi: 2010
• Doi Numarası: 10.1007/s10157-009-0214-2
• Dergi Adı: CLINICAL AND EXPERIMENTAL NEPHROLOGY
• Sayfa Sayıları: ss.22-27

Özet

Nonsteroidal anti-inflammatory drugs act by inhibiting the rate-limiting enzymes cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2), which are important in prostanoid formation. The aim of this experimental study was to examine the effects of selective Cox-2 inhibitor, rofecoxib, with or without furosemide, on urine and serum electrolytes, creatinine clearance, plasma renin activity (PRA), and Cox-2 expression in the renal cortex.