Effects of selective Cox-2 inhibitor, rofecoxib, alone or combination with furosemide on renal functions and renal Cox-2 expression in rats

Kose F., Besen A., Paydaş S., Balal M., Gönlüşen G., Inal T., ...More

CLINICAL AND EXPERIMENTAL NEPHROLOGY, vol.14, pp.22-27, 2010 (SCI-Expanded) identifier identifier identifier


Nonsteroidal anti-inflammatory drugs act by inhibiting the rate-limiting enzymes cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2), which are important in prostanoid formation. The aim of this experimental study was to examine the effects of selective Cox-2 inhibitor, rofecoxib, with or without furosemide, on urine and serum electrolytes, creatinine clearance, plasma renin activity (PRA), and Cox-2 expression in the renal cortex.