The efficacy of F-18-FDG PET/CT in the preoperative evaluation of pancreatic lesions


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Akçam A. T. , Teke Z., Sarıtaş A. G. , Ulku A., Güney İ. B. , Rencüzoğulları A.

ANNALS OF SURGICAL TREATMENT AND RESEARCH, cilt.98, ss.184-189, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 98
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4174/astr.2020.98.4.184
  • Dergi Adı: ANNALS OF SURGICAL TREATMENT AND RESEARCH
  • Sayfa Sayıları: ss.184-189

Özet

Purpose: Since the treatment strategy for benign and malignant pancreatic lesions differ, we aimed to evaluate the clinical
value of PET/CT in the diagnosis and management of pancreatic lesions.
Methods: Ninety patients who had a histologically confirmed pancreatic lesion were studied. Receiver operating
characteristic (ROC) curve analysis was used to investigate the ability of PET/CT to differentiate malignant lesions from
benign tumors.
Results: The malignant and benign groups comprised 64 and 26 patients, respectively. Despite the similarity in the size
of primary tumors (P = 0.588), the mean maximum standardized uptake values (SUVmax) obtained from PET/CT imaging
were significantly higher in malignant lesions (9.36 ± 5.9) than those of benign tumors (1.04 ± 2.6, P < 0.001). ROC analysis
showed that the optimal SUVmax cutoff value for differentiating malignant lesions (to an accuracy of 91%; 95% confidence
interval, 83%–98%) from benign tumors was 3.9 (sensitivity, 92.2%; specificity, 84.6%).
Conclusion: PET/CT evaluation of pancreatic lesions confers advantages including fine assessment of malignant potential
with high sensitivity and accuracy using a threshold SUVmax value of 3.9.
[Ann Surg Treat Res 2020;98(4):184-189]
Key Words: Chronic pancreatitis, Pancreas, Pancreatic neoplasms, Pancreatic pseudocyst, Positron emission tomography
computed tomography