Configuration-Encoded Cell Alignment by Light-Gated Silicon Photovoltaic Microcell Arrays
Advanced Functional Materials, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2026
- Doi Numarası: 10.1002/adfm.78968
- Dergi Adı: Advanced Functional Materials
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Applied Science & Technology Source, Chemical Abstracts Core, Chimica, Compendex, INSPEC, MEDLINE, Academic Search Ultimate (EBSCO)
- Anahtar Kelimeler: cell alignment, electrical cell stimulation, photovoltaic microcell arrays, tissue patterning
- Çukurova Üniversitesi Adresli: Hayır
Özet
Cellular alignment through external stimulus offers dynamic control and functional adaptation that static topological or adhesive cues cannot provide. Static alignment strategies can impose defined cellular organization, but these cues are typically fixed after fabrication. By contrast, electric fields provide active bioelectrical cues that can modulate cell orientation, migration, and signaling, making them attractive for regulating cell alignment. However, current electrical-stimulation platforms still provide limited capability to encode cell organization with microscale spatial precision. Here, we present a new light-gated bioelectrical stimulation platform enabled by patterned photovoltaic microcell arrays. Those microcells transduce light into localized electric fields for microscale spatial modulation of cell (e.g., fibroblast) behavior pertient to cell orientation and migration. With pulsed light stimulation, the photovoltaic microcell arrays generate a photoelectrical response that can produce local electrical cues associated with pattern-dependent alignment of fibroblasts perpendicular to the field lines. These results indicate that spatially patterned photovoltaic stimulation can be used not only to stimulate other cell types but also to influence fibroblast alignment and associated molecular responses upon illumination, without wired electrodes. Our study provides a wireless strategy for exploring fibroblast galvanotaxis and suggests a potential approach to guide fibroblast alignment and geometry-dependent organization, and further tissue morphogenesis.