Involvement of potassium channels and nitric oxide in tramadol antinociception

YALCIN, P; Aksu, FAZİLET

doi:10.1016/j.pbb.2004.10.020

Involvement of potassium channels and nitric oxide in tramadol antinociception

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YALCIN P., Aksu F.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, vol.80, no.1, pp.69-75, 2005 (SCI-Expanded)

Publication Type: Article / Article
Volume: 80 Issue: 1
Publication Date: 2005
Doi Number: 10.1016/j.pbb.2004.10.020
Journal Name: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.69-75
Çukurova University Affiliated: Yes

Abstract

It has been considered that tramadol, a centrally acting analgesic, shows its effect via opiatergic, noradrenergic, and serotonergic systems. It has a low affinity for opioid receptors, and its effect can be partly blocked by naloxone. Since the noradrenergic and serotonergic mechanisms are still unknown, other systems which are associated with pain and analgesia may have a role on the antinociceptive effect of tramadol.