Involvement of potassium channels and nitric oxide in tramadol antinociception

YALCIN P., Aksu F.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, cilt.80, sa.1, ss.69-75, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 80 Sayı: 1
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.pbb.2004.10.020
  • Dergi Adı: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.69-75
  • Çukurova Üniversitesi Adresli: Evet

Özet

It has been considered that tramadol, a centrally acting analgesic, shows its effect via opiatergic, noradrenergic, and serotonergic systems. It has a low affinity for opioid receptors, and its effect can be partly blocked by naloxone. Since the noradrenergic and serotonergic mechanisms are still unknown, other systems which are associated with pain and analgesia may have a role on the antinociceptive effect of tramadol.