Involvement of potassium channels and nitric oxide in tramadol antinociception


YALCIN P., Aksu F.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, cilt.80, ss.69-75, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 80 Konu: 1
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.pbb.2004.10.020
  • Dergi Adı: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
  • Sayfa Sayıları: ss.69-75

Özet

It has been considered that tramadol, a centrally acting analgesic, shows its effect via opiatergic, noradrenergic, and serotonergic systems. It has a low affinity for opioid receptors, and its effect can be partly blocked by naloxone. Since the noradrenergic and serotonergic mechanisms are still unknown, other systems which are associated with pain and analgesia may have a role on the antinociceptive effect of tramadol.