Synthesis, characterization and DNA binding studies of platinum(II) complexes with benzimidazole derivative ligands


TARI Ö. , Gumus F., Acik L., Aydin B.

BIOORGANIC CHEMISTRY, cilt.74, ss.272-283, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 74
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.bioorg.2017.08.015
  • Dergi Adı: BIOORGANIC CHEMISTRY
  • Sayfa Sayısı: ss.272-283

Özet

The aim of this study was to synthesize and evaluate plasmid DNA interaction of new platinum(II) complexes with some 2-substituted benzimidazole derivatives as carrier ligands which may have potent anticancer activity and low toxicity. Twelve benzimidazole derivatives carrying indole, 2-/or 3-/or 4-methoxyphenyl, 4-methylphenyl, 3,4-dimethoxyphenyl, 3,4,5-trimethoxyphenyl, 4-methoxybenzyl, 3,4,5-trimethoxybenzyl, 3,4,5-trimethoxystyryl, 3,4,5-trimethoxybenzylthio or dimethylamino ethyl groups in their position 2 and twelve platinum(II) complexes with these carrier ligands were synthesized. The chemical structure of the platinum complexes have been characterized by their elemental analysis and FIR, H-1 NMR and mass spectra and their H-1 NMR and FIR spectra were interpreted by comparison with those of the ligands. The interaction of all the ligands and their complexes with plasmid DNA and their restriction endonuclease reactions by BamHI and HindIII enzymes were studied by agarose gel electrophoresis. It was determined that complex 1 [dichloro-di(2-(H-1-indole-3-yl) benzimidazole) platinum( II)center dot 2H(2)O] has stronger interaction than carboplatin and complex 10 [ dichloro-di(2-(3,4,5-trimethoxys tyryl) benzimidazole) platinum(II)center dot 2H(2)O] has stronger interaction than both carboplatin and cisplatin with plasmid DNA. (C) 2017 Elsevier Inc. All rights reserved.