Low Serum Beta-2 Microglobulin Level: A Possible Biomarker for Sarcopenia in the Elderly Population

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Bayram E., Kanat Şahin C.

MEDICINA (KAUNAS, LITHUANIA), vol.60, no.1879, pp.1-12, 2024 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 60 Issue: 1879
  • Publication Date: 2024
  • Doi Number: 10.3390/medicina60111879
  • Journal Name: MEDICINA (KAUNAS, LITHUANIA)
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Directory of Open Access Journals
  • Page Numbers: pp.1-12
  • Çukurova University Affiliated: Yes

Abstract


twere accepted as having definitive sarcopenia. Results: The mean age of the 251 older adults includedin the study was 72.19 ± 6.11 years. The prevalence of sarcopenia in individuals aged 65 years andover was found to be 5.2%. Serum beta-2 microglobulin levels were statistically significantly lower insarcopenic participants compared to the control group (p = 0.002). The optimal cut-off value for serumbeta-2 microglobulin level was 2.26 mcg/mL, and values lower than this point were found to bediagnostic for sarcopenia. Regarding the cut-off value, the sensitivity was 92.31% and the specificitywas 80.77%, the positive predictive value was 70.59%, the negative predictive value was 95.45%, theYouden index was 0.731, and the area under the curve value was 0.901. Individuals who had beta-2microglobulin levels below 2.26 mcg/mL were found to have a 10.75 times higher risk of sarcopenia.Conclusions: A low serum beta-2 microglobulin level has the potential to be an important candidatebiomarker for the diagnosis of sarc