The Effect of Deferoxamine on Superoxide Dismutase and Histopathological Changes Following Experimental Spinal Cord Injury

ÖZSOY K. M., GEZERCAN Y., ÇETİNALP N. E., AÇIKALIN A., Oktay K., ERDOĞAN Ş., ...More

JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, vol.32, no.2, pp.372-381, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 2
  • Publication Date: 2015
  • Journal Name: JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.372-381
  • Çukurova University Affiliated: Yes

Abstract

Aim: Primary traumatic spinal cord injury is defined as the injury occurring at the time of the trauma. The metabolic and biochemical processes lead to the secondary trauma in the following hours after the primary trauma. Free radicals and ischemic reperfusion injury are two factors which play role in secondary injury. An iron chelating agent deferoxamine has treatment effect on secondary injury mechanisms by binding free iron ion. This study is based on these effects of deferoxamine.