Novel highly functionalized benzoylaminocarbothioyl pyrrolidine from benzoylisothiocyanate and substituted pyrrolidine derived from alpha-aminoasit ester via imine-azomethine ylide-1,3-dipolar cycloaddition cascade.


DÖNDAŞ H. A. , Altinbas O.

HETEROCYCLIC COMMUNICATIONS, cilt.10, ss.167-173, 2004 (SCI İndekslerine Giren Dergi) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10
  • Basım Tarihi: 2004
  • Dergi Adı: HETEROCYCLIC COMMUNICATIONS
  • Sayfa Sayıları: ss.167-173

Özet

A series of novel highly functionalized benzoylaminocarbothioyl pyrrolidines were prepared by the reaction of benzoylisothiocyanate with substitueted pyrrolidine derived from alpha-aminoasit ester via metal catalsed imine -azomethine ylides-1,3-Dipolar Cycloaddition in excellent yield. An example of chiral version benzoylaminocarbothioyl pyrrolidine were also reported. The chirality oryginated from menthyl acrylate as chiral dipolarophile in the cycloaddition cascade and induced three novell chiral centres.